H1-antihistamines for the treatment of anaphylaxis with and without shock

October 2017

Emergency Care

Country of origin: USA

Anaphylaxis is a rare, but potentially life-threatening emergency. Evidence suggests that incidence may be increasing rapidly. Common triggers of anaphylaxis include a variety of foods, drugs and insect venoms.

H1-antihistamines are commonly used for the emergency treatment of anaphylaxis although the evidence underpinning this treatment is unclear. A systematic review of the literature has been conducted, searching key databases for high quality published and unpublished material on this subject; in addition, experts in this area and relevant pharmaceutical companies were contacted.

The searches failed to retrieve any randomised controlled trials on this subject. The review concludes there is no evidence from randomised controlled trials to support the use of H1-antihistamines in the emergency management of anaphylaxis.

The Cochrane review is available online.

Resources

Clinical Pain Advisor. December 2018 Clinical Pain Advisor is a free, simple to use, medical app that offers pain medicine healthcare professionals a...
Managing Head Injury. December 2018 The National Institute for Health and Clinical Excellence (NICE) has issued an updated guideline on the early care of...
OrthoFlow pocket orthopaedic specialist. December 2018 Welcome to OrthoFlow…the orthopaedic specialist in your pocket! This new way of learning is designed to help you diagnose...
The CDC Clear Communication Index November 2018 The CDC Clear Communication Index (Index) is a research-based tool to help you develop and assess public communication...
Prevention of HAI Observation Tools November 2018 Patients deserve and expect safe care free of preventable complications, such as healthcare-associated infections. Hospital...
Visual communication can benefit all audiences November 2018 Visuals, such as pictures, drawings, charts, graphs and diagrams, can be effective tools for communicating health...
Emergency Preparedness, Resilience and Response (EPRR) November 2018 The NHS needs to plan for, and respond to, a wide range of incidents and emergencies that could affect health or patient...
Emergency Department design toolkit October 2018 The Design Council has published a toolkit for NHS managers, clinicians and designer and healthcare planners who want to...
Research on treating bacterial meningitis October 2018 Bacterial meningitis in children is a devastating condition, which if left untreated can lead to deafness, seizures,...
WISER application for first responders October 2018 WISER is an application designed to assist first responders in hazardous material incidents. It provides a wide range of...
Search by Keyword