Urinary alkalinisation for acute chlorophenoxy herbicide poisoning

October 2017

Emergency Care

Country of origin: USA

Acute poisoning with chlorophenoxy herbicides such as 2,4-D and MCPA is reported world wide, potentially causing severe toxicity and death. Since there is no antidote for chlorophenoxy herbicides, treatments such as urinary alkalinisation have been used to increase the clearance of these poisons from the body. Although urinary alkalinisation was first trialled over 30 years ago, it is not currently used routinely for the treatment of patients with acute chlorophenoxy poisoning.

This review looked for studies where this treatment had been given to poisoned patients. No studies of sufficient quality were identified and therefore routine use of this approach to treatment cannot be recommended. However, due to the poor outcomes in patients who present with severe toxicity it may have a role in addition to standard intensive care support.

The Cochrane review is available online.

Resources

Emergency Department design toolkit October 2018 The Design Council has published a toolkit for NHS managers, clinicians and designer and healthcare planners who want to...
Research on treating bacterial meningitis October 2018 Bacterial meningitis in children is a devastating condition, which if left untreated can lead to deafness, seizures,...
WISER application for first responders October 2018 WISER is an application designed to assist first responders in hazardous material incidents. It provides a wide range of...
Medicines for Children: practical and reliable information for parents and carers September 2018 The vision of Medicines for Children is that any parent, wherever they are, have information on their child’s medicines...
Clinical Pain Advisor September 2018 Clinical Pain Advisor is a free, simple to use, medical app that offers pain medicine healthcare professionals a...
Guidance: Know What To Do About Flu September 2018 The Centers for Disease Control and Prevention (CDC) part of the Department of Health and Human Services (HHS) has released...
National Hip Fracture Database September 2018 It is estimated that there are 70,000 hip fractures a year in the UK[1] and this is only set to increase as the population...
Managing Head Injury September 2018 The National Institute for Health and Clinical Excellence (NICE) has issued an updated guideline on the early care of...
Guidance for Health Staff on Identifying and Supporting Victims of Human Trafficking September 2018 Guidance has been published which provides guidance and sets out actions for healthcare staff who suspect that their...
The science behind drug abuse June 2018 Knowledge is power, and a NIDA educational product empowers teens to make healthy decisions about drugs. "NIDA for Teens:...
Search by Keyword