Maternal Risk Factors for Abnormal Placental Growth
Country of origin: USA
Click for Full Details: www.biomedcentral.comPrevious studies of maternal risk factors for abnormal placental growth have focused on placental weight and placental ratio as measures of placental growth. Researchers sought to identify maternal risk factors for placental weight and two neglected dimensions of placental growth: placental thickness and chorionic plate area.
An analysis was conducted of 24,135 mother-placenta pairs enrolled in the National Collaborative Perinatal Project, a prospective cohort study of pregnancy and child health. The researchers defined growth restriction as < 10th percentile and hypertrophy as > 90th percentile for three placental growth dimensions: placental weight, placental thickness and chorionic plate area. They constructed parallel multinomial logistic regression analyses to identify (a) predictors of restricted growth and (b) predictors of hypertrophic growth.
Black race was associated with an increased likelihood of growth restriction for placental weight, thickness and chorionic plate area, but was associated with a reduced likelihood of hypertrophy for these three placental growth dimensions. An increased likelihood of growth restriction for placental weight and chorionic plate area among mothers with hypertensive disease at 24 weeks or beyond was observed. Anaemia was associated with a reduced likelihood of growth restriction for placental weight and chorionic plate area. Pre-pregnancy BMI and pregnancy weight gain were associated with a reduced likelihood of growth restriction and an increased likelihood of hypertrophy for all three dimensions of placental growth.
The research article concludes that maternal risk factors are either associated with placental growth restriction or placental hypertrophy not both. Our findings suggest that the placenta may have compensatory responses to certain maternal risk factors suggesting different underlying biological mechanisms.
Full text of the BMC Pregnancy and Childbirth article is available online.
Click for Full Details: www.biomedcentral.com
inPracticeŽ Oncology. December 2018
The CDC Clear Communication Index November 2018
Visual communication can benefit all audiences November 2018
Sublux radiology app for all medical providers October 2018
PubMed Hub TV app October 2018
Study finds HPV from Oral Sex is linked to Throat Cancer September 2018
Anticoagulation Manager September 2018
Web forum for schizophrenia researchers September 2018
Harm Reduction September 2018